Fort McPherson (Gwich'in: Teetł'it Zheh [tʰeː.tɬʼɪtʰ ʒɛh], at the head of the waters) is a hamlet located in the Inuvik Region of the Northwest Territories, Canada.

It is located on the east bank of the Peel River and is 121 km (75 mi) south of Inuvik on the Dempster Highway.

Fort McPherson was the starting point of Francis Joseph Fitzgerald's famous tragic journey of "The Lost Patrol".

In 1969, the area comprising the boundaries of the community of Fort McPherson, as it was mapped in 1898, was designated a National Historic Site of Canada, in recognition of the fact that the site had served as the principal Hudson's Bay Company trading post in the MacKenzie Delta region for over 50 years, and had been the first North-West Mounted Police post in the Western Arctic.

[8] Fort McPherson is accessible by road all year from Dawson City and Whitehorse, Yukon, with the exception of spring break-up and fall freeze-up on the Peel River.