in unincorporated Jackson County, Missouri, in the Kansas City metropolitan area, adjacent to Independence.

[3][4] It belongs to the Fort Osage R-1 School District and serves a section of northern Independence.

It is named after the Fort Osage National Historic Landmark along the Missouri River in nearby Sibley, Missouri.

Fort Osage's baseball team has appeared in three 4A state championships having won in 1991 and 1997, and finishing as runners up in 1996.

Since 2009, Fort Osage's football team has appeared in the Class 5 state championship game 5 times in 2009, 2012, 2015, 2018, and 2022.