After de La Salle became ill during his expedition's return up the Mississippi in 1682, he was required to spend forty days at the fort until he had recuperated.
[2] On top of the Mississippi River bluffs in Tennessee, La Salle's party constructed a stockade fortification.
Ten days after his disappearance, the missing member of the expedition found his way back to the camp, unharmed but starving.
[4][5] The Tennessee Encyclopedia of History and Culture suggests that Fort Prudhomme was built on the second Chickasaw Bluff, south of the Hatchie River, near modern-day Randolph in Tipton County.
[3][7] Other sources assume that "La Salle built Fort Prudhomme, possibly on the site of present-day Memphis", on the fourth Chickasaw Bluff below the mouth of the Wolf River, in what would later become Shelby County.