French settlements and tobacco plantations were established in Natchez territory, with the fort serving as the local seat of colonial government.

[1] They destroyed the entire French settlement, killing nearly all the men and taking hundreds of women and children captive.

Following the Treaty of Paris in 1763 after the British won the Seven Years' War, the French ceded the fort and part of present-day Louisiana to British control (with New Orleans and the land west of the Mississippi River going to Spain).

After Bernardo de Galvez conquered Baton Rouge (1779), Fort Panmure capitulated without further Spanish action.

Spanish military intervention was only required in 1781 to put down a rebellion by local settlers loyal to Britain.