The film features Star Cinema's most prominent young actresses: Toni Gonzaga, Bea Alonzo, Angel Locsin and Shaina Magdayao, as the four sisters attempting to stop the wedding of their younger brother played by Enchong Dee.

Actress Angelica Panganiban was originally part of the main cast but was pulled out and replaced by Shaina Magdayao.

Bobbie, the second sister, is a corporate communications manager in New York living with her boyfriend Tristan and his daughter Trixie.

Teddie, unable to afford a plane ticket, convinces her colleague Frodo to return to Manila with her, pretending to be a couple.

When the family reunites, the sisters express their concerns about CJ's abrupt decision to marry, offending him and prompting apologies.

To avoid wasting the preparations and expenses, Bobbie marries Tristan instead, with the Salazars wearing the Bayags' gowns.

The prequel will also be directed by Giselle Andres, an assistant director in the original film, however, Mae Cruz-Alviar replaced her instead, and it will be set during the Salazar siblings' teenage years.

The prequel will star Charlie Dizon, Alexa Ilacad, Gillian Vicencio, and Belle Mariano as Teddie, Bobbie, Alex, and Gabbie, respectively.