It is easily one of the most recognizable buildings in the city's skyline, owing to the elaborate Hellenic architecture in the upper portion of the tower, which was modeled to resemble reconstructions of the Mausoleum at Halicarnassus.

[8] when workers began removing the "Central Trust" signage from the building and replacing it with a similarly-styled red-neon-lettered sign.

The site of the tower was previously occupied by the U.S. Post Office and Customs House and also at a later time by the Chamber of Commerce Building.

The 4th & Vine Tower was originally built as the headquarters for The Union Central Life Insurance Company,[10] which moved out in 1964.

[13] The building, along with the nearby skyscraper, the Carew Tower, was featured in the opening and closing of the daytime drama The Edge of Night from 1967 to 1980.