The center is part of the Temple University Health System (TUHS) and specializes in the treatment and prevention of cancer.

In 1967 a large wing of the hospital was constructed based on a design by Vincent G. Kling using steep slopes of poured concrete and roof tiles by Ludowici.

On December 15, 2011, Fox Chase Cancer Center and Temple University Health system signed an affiliation agreement.

[4] Under the agreement, Fox Chase has connected and extended its current operations into the adjoining 176-bed and 33-acre Jeanes Hospital, which is already a part of the Temple University Health System.

Annual hospital admissions average about 3,500 and outpatient visits to physicians exceed 125,000 a year.