[2] The high school was named after three loyal noblemen, the Buzești brothers, Preda, Radu, and Stroe Buzescu,[4] who were the inseparable, strongest military supporters of voivode Michael the Brave; their noble blood line goes back to 1461 AD.

[5][6] As a high school it was formally established in 1882 as "Gimnaziul Real" by an edict of "Ministerul Cultelor" (approved by Petre S. Aurelian, the Minister of Culture at the time), with a predominantly science teaching for boys.

On January 9, 1910, however, Spiru Haret — then Minister of Education and Culture ("Ministerul Instrucțiunii și Cultelor") — announced that he approved the gymnasium to be called by the name of "Frații Buzești".

The school's two rigidly disciplinarian teachers in the 1960s were Sică-Anastasie Petrescu for Mathematics, and Teodoreanu — an elderly Russian Bessarabean — for Physics.

However, the most remarkable headmaster in the entire history of the school was — between 1920 and 1940 — the professor of natural sciences Ion P. Ionescu-Argetoaia,[9] with a doctorate in Geology, who gave up a professorship at the University of Timișoara, as well as an assistant professorship at the Sorbonne, in Paris, in order to join "Frații Buzești" as its leader; he was the first to succeed in securing the approval by the Ministry of Education ("Ministerul Instrucțiunii") for the construction of the monumental building of the high school that continues to be used today.