Men's programs include baseball, cross country, football, basketball, ice hockey, and soccer.

The university also offers a wide variety of intramural programs that include everything from badminton, to golf, to dodgeball.

[4] Framingham State University adopted its mascot the ram in 1967, after a school-wide vote on what should represent the school.

On November 28, 2022, the Framingham State Rams (2-5 overall, 0–0 in MASCAC play) took on the Bryant University Bulldogs of NCAA Division I's America East Conference (6-1 overall, 0–0 in America East play) in a non-conference exhibition game at the Chace Athletic Center in Smithfield, Rhode Island.

Although the Rams lost by a final score of 98–44,[12] the game was notable due to freshman guard Julius Goines's dunk in the beginning minutes of the second half.

They went on to become MASCAC tournament champions for the first time ever beating the Worcester State Lancers at home by a final score of 66-51 led by MASCAC tournament MVP senior guard Mary Kate O'Day and with a posted attendance of 1,214 people, which represented the biggest home crowd in program history and Logan Gymnasium history.

[18][19] With that win the Rams were awarded with an automatic berth into the 2020 NCAA Division III women's basketball tournament which was the first time in program history that the Rams appeared in the NCAA Division III women's basketball tournament.

On March 4, 2022, Smith beat Framingham State by a final score of 61–51 with a posted attendance of 450 people, which marked the closest NCAA tournament game in program history to date.

Second this game was a rematch of the 2022 NCAA Division III women's basketball tournament first round.

[30] In the 2023–24 season the Rams are scheduled to appear in the 13th annual D3hoops.com Classic at the South Point Arena in Las Vegas, Nevada for the first time ever in program and school history.

On October 9, 1972, the football team played its first game against the Boston State College Warriors at Bowditch Field in Framingham, Massachusetts.

On September 10, 1982, the football team played its first "home" game against the Western New England College Golden Bears at Maple Street Field in Framingham, Massachusetts.

Framingham State won 7-6 and the game ball was presented to B.R.D Justin McCarthy being FSC's number one fan.

The Rams won the Massachusetts State College Athletic Conference (MASCAC) regular season championship four straight years (2010, 2011, 2012, 2013).

The Rams participated in the 2013 NCAA Division III Football Championship, losing to SUNY Cortland in the first-round.

In 2015 the Rams were MASCAC Champions and participated in the 2015 NCAA Division III Football Championship, losing to Wesley College 42–22.

In 2018 the rams were MASCAC Champions and participated in the 2018 NCAA Division III Football Championship losing to Brockport State in the first round 40–27.

In 2019 the Rams were MASCAC Champions and participants in the 2019 Division III Football Championship losing to Wesley College in first round 58–21.

[38][39] On April 30, 2022, the Seattle Seahawks of the National Football League (NFL) signed defensive end Joshua Onujiogu as an undrafted free agent.

In the 2023–24 season the MASCAC division of the Little East became its own separate conference and now currently plays a double round robin in-conference schedule going forward.

On February 26, 2022, the 7th seeded Framingham State Rams (3–21–1 overall, 1–16–1 in MASCAC play) upset the 2nd seeded Fitchburg State Falcons (17–6–1 overall, 14–3–1 in MASCAC play) at the Wallace Civic Center in Fitchburg, Massachusetts, on a 1–0 overtime win in the MASCAC Men's Hockey Tournament quarterfinal game with the overtime game-winning goal scored by freshman forward Kaleb Kinskey on a power play goal with 12 minutes and 48 seconds to go in the first overtime period.

[54] Accomplishments The Framingham State women's ice hockey team began play in the 2024–25 season.

[59] The Rams were led by first-year head coach Devyne Doran, and MASCAC tournament MVP, sophomore midfielder Rachel Erickson.

Reynolds told his squad to alert the referees to the mistake, and after some discussion, they decided to uphold the decision, giving the Rams a 1–0 lead.