François Loeser (born August 25, 1958) is a French mathematician.

He was awarded an ERC Advanced Investigator Grant in 2010 and has been a Plenary Speaker at the European Congress of Mathematics in Amsterdam in 2008.

In 2014 Loeser was an Invited Speaker at the International Congresses of Mathematicians in Seoul.

In 2015 he was elected as a fellow of the American Mathematical Society "for contributions to algebraic and arithmetic geometry and to model theory".

He is a specialist of algebraic geometry and is best known for his work on motivic integration, part of it in collaboration with Jan Denef.