[1] Another member of his extended family, François-Emmanuel de Crussol d'Uzès, served as Bishop of La Rochelle from 1768 to 1789.
[2] He was ordained a priest at the age of 22 and had to plead against the Duke of Uzès in order to obtain an ecclesiastical benefice for his family.
He was designated as Bishop of Blois in 1724, confirmed on 17 November 1724, and consecrated in January 1735 by Charles-Gaspard-Guillaume de Vintimille du Luc, the Archbishop of Paris.
[3] In his diocese of Blois, he appointed as vicar general his friend, Christophe de Beaumont, who would be named Bishop of Bayonne in 1741 before himself acceding to the Archbishopric of Paris in 1746.
[4] In 1740, François de Crussol received the command of the Abbey of Saint-Germain d'Auxerre and was transferred and promoted to the Archbishopric of Toulouse in 1753, confirmed in September;[1] taking possession of the Archdiocese on 12 January 1755.