[1][2] She married her cousin George Simpson of the Hudson's Bay Company in February 1830.

The fur trading post on Rainy Lake was renamed Fort Frances in her honour.

After her arrival in Rupert's Land, First Nations women married to Hudson's Bay Company officials were excluded from respectable society.

She returned to London in 1833 to recover but her health continued to decline during three subsequent pregnancies.

[1][2] She visited Lachine, just upstream of Montreal, with her husband in 1838 and, in 1845, moved there permanently.