Her father was the third son of Sir William Twysden, 5th Baronet of Roydon Hall, East Peckham, Kent, by his wife and second cousin Jane Twisden.

[4][5][6] In March 1770, barely a month past her 17th birthday, Frances married George Villiers, the 4th Earl of Jersey (1735–1805), a 34-year-old peer who had succeeded his father in August 1769.

Since Lady Jersey enjoyed the favour of Queen Charlotte, even the displeasure of George III was not enough to threaten her position, and she continued to run the Prince of Wales' life and household for some time.

According to Archaeologia Cantiana,The home of the Bishop's daughter Frances, Lady Jersey, a favourite of George IV, became a society gambling rendezvous, at which the reputations of her cousins were in no way enhanced.

[6]Though it may be said the death of her husband—who had narrowly avoided imprisonment in 1802[1]—in 1805 left her without the means to support her rank,[8] her son increased her jointure to £3,500 per annum and settled her debts many times.