Frances was one of the Hampton Court Beauties painted by Sir Godfrey Kneller for Queen Mary II.
Her father was Sir Thomas Whitmore, (son of Sir Thomas Whitmore, 1st Baronet), and her mother was Hon.
She married Sir Richard Myddelton, 3rd Baronet (1655–1716) in c.1686.
They had three children: As one of the Hampton Court Beauties, Frances Myddelton (Nee Whitmore) was known as Lady Myddelton, coincidentally, her husband's aunt is the Mrs Myddelton of the Windsor Beauties and her own mother is Lady Whitmore of the Windsor Beauties.
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