Early in Harper's career she was a soloist with Dance Theater of Harlem.
[5] In 2005, she founded the non-profit dance company The Francesca Harper Project.
[6] After deliberation by Robert Battle, artistic director of the Alvin Ailey American Dance Theater and Bennett Rink, Director of the Alvin Ailey Dance Foundation, Harper was named artistic director of The Alvin Ailey II Company in 2021.
[7] Harper was a ballet consultant for the film Black Swan,[8] and has appeared as a dancer in the television series Boardwalk Empire.
[9] She is currently engaged as an Executive Producer with Sony Pictures to develop a new project.