Francesco Armellini Pantalassi de' Medici (13 July 1470 – 8 January 1528)[1] was a cardinal of the Roman Catholic Church.

He was made a cardinal on the 6 July 1517 by Pope Leo X, to the titular church of San Callisto.

He was bishop of Gerace e Oppido in 1517, and archbishop of Taranto in 1525.

In the rione Borgo the cardinal let built a magnificent palace bearing his name.

The historian Paolo Giovio wrote that the exactions and greed that the Cardinal showed in running the papal finances, as Camerlengo of the Holy Roman Church from 1521, had played a large part in causing the 1527 sack of Rome, because he had alienated the Roman population.