Francesco D'Afflitto (died 11 October 1593) was a Roman Catholic prelate who served as Bishop of Scala (1583–1593).
On 27 June 1583, Francesco D'Afflitto was appointed during the papacy of Pope Gregory XIII as Bishop of Scala.
[1][3] On 13 November 1583, he was consecrated bishop by Giulio Rossino, Archbishop of Amalfi, with Giovanni Bernardino Grandopoli, Bishop of Lettere-Gragnano, and Giovanni Agostino Campanile, Bishop of Minori, serving as co-consecrators.
[3] He served as Bishop of Scala until his death on 11 October 1593.
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