Margherita was living in Avignon with her mother after her father was executed for his role in an anti-republican plot and her brothers were exiled.

[1] As thus Datini spent long periods of time away from Prato, where his wife continued to live, over the next 27 years, the couple frequently corresponded through letters.

From June 1400 to September 1401, the two, along with Datini's illegitimate daughter Ginevra, fled from Prato to Bologna in fear of the Black Death.

[7] In 1870, 500 account books and 150,000 papers relating to Datini's business were discovered in a stairwell of the couple's mansion in Prato.

[8] These papers provide insight into both Datini's business as well as the merchant class in general as it existed in the fourteenth and fifteenth centuries.