He created the role of Prunier in the original 1917 production of Puccini's La rondine at the Grand Théâtre de Monte Carlo, a role which he performed at many other opera houses including the Teatro Comunale di Bologna.
Over the next several years he played mostly leading roles at the Teatro Costanzi in Rome including Rodolfo in Puccini's La bohème, Fenton in Verdi's Falstaff, and the Ernesto in Donizetti's Don Pasquale.
In 1921, he sang the role of doctor Cajus in Verdi's Falstaff at La Scala and in 1922 was Filipeto in the company's first production of Ermanno Wolf-Ferrari's I quatro rusteghi.
In 1926 he created the role of Emperor Altoum in the original production of Puccini's Turandot at La Scala.
Other roles that Dominici performed at La Scala include David in Wagner's Die Meistersinger von Nürnberg, Monostatos in Mozart's The Magic Flute, and the Neipperg in Umberto Giordano's Madame Sans-Gêne.