He was the third son of Francesco I Gattilusio and Maria Palaiologina, the sister of the Byzantine emperor John V Palaiologos.
[4] This act, as well as the location of Lesbos, resulted in his home being frequently visited by traveling important personages from Western Europe: "this was their last stopping-place in Latin lands on their way to Constantinople or to Asia," William Miller writes.
[4] Ruy Gonzáles de Clavijo, the ambassador Henry III of Castile sent to Tamerlane in 1403, stayed with Francesco at one point in his outward journey, and records he met John VII Palaiologos, "the young Emperor" in his household; de Clavijo notes that John "resided a good deal in this island".
A clue to her identity is the statement of Konstantin the Philosopher, biographer of Stefan Lazarević, who wrote around 1431 that Stefan's wife (a daughter of Francesco II) was "through her mother a niece of the emperor Manuel, from whom the lords and lineage of her family were named Palaiologi."
After having been bitten by a scorpion, the number of people rushing to his aid resulted in the wooden floor of his room collapsing under their combined weight.