Francesco Maria Pico (Concordia sulla Secchia, 30 September 1688 – Madrid, 26 November 1747), also known as Francesco Maria II Pico della Mirandola to distinguish him from his father, was an Italian nobleman, third Duke of Mirandola and fourth Marquis of Concordia.

His rule began in 1706 and he sided with France in the War of the Spanish Succession: Concordia was set on fire and devastated.

As a consequence of this, in 1706 in Vienna he was declared forfeit for felony against the Holy Roman Empire and expelled from the Duchy of Mirandola by Prince Eugene of Savoy.

In 1710, the Duchy of Mirandola was sold to Rinaldo d'Este, Duke of Modena for the sum of 200,000 Spanish doubles (equivalent to a tonn of gold).

On 14 June 1716, he married Duchess María Teresa Spínola y de la Cerda, daughter of Duke Carlos Felipe Antonio Spinola (fourth Duke of Sextus and Marquis of Los Balbases as well as Grande de España), who drowned on 15 September 1723 during a flood that swept through their house in Madrid;[3] Francesco Pio di Savoia (Francisco Pío de Saboya y Moura) also died in the tragedy.