In his work he shows a preference for nocturnal effects which reveals the influence of Caravaggio and his followers, the so-called Caravaggisti.
He was also in contact with Lorenzo Magalotti, an important personage in the organization of the cultural projects of the Barberini.
His early works show the influence of his father and of Alessandro Casolani who painted in the Sienese Mannerist style.
[6] Another important influence on his work was Gerrit van Honthorst, who was known for his mastery of nocturnal effects, which had earned him in Italy the nickname 'Gherardo delle Notti' ("Gerard of the nights").
[7] Rustici's handling of light followed the Dutch-Flemish model of van Honthorst and blended it with a wholly Tuscan form of Classicism.