Born at Florence, he first trained with his father, the Milanese painter Luigi Sabatelli, then later in Rome and Venice.
In 1823, he moved to Florence on the invitation of the government of Leopold II,[1] and became a professor in the Accademia di Belle Arti.
Among his works were Pier Capponi che lacera i turpi capitoli, Joseph sold by brothers at the cistern of Dothai, and Creation of the Soul.
When his father Luigi left Milan to paint the Salone dell'Iliade (Hall of the Illiad) at the Pitti Palace in Florence, it was his younger son, Francesco, who helped him in this work.
When Leopoldo Medici saw the work, he awarded a stipend for Francesco to study in Rome and Venice Francesco went to paint a lunette in the hall where his father had worked, painting Hector che arsa una nave greca e cosi adempiuto il decreto dei fati, viene da Aiace Talamonio costretto a indietreggiare.