Francesco del Giudice (7 December 1647 – 10 October 1725) was a Roman Catholic cardinal from 1690 to 1725 who also held a variety of other ecclesiastical and governmental offices.

[1] Pope Alexander VIII named him a cardinal priest in the consistory of 13 February 1690, with dispensation for not having received the minor orders.

[3] He briefly lost royal favor in July 1714 when he issued an edict condemning certain regalist writings into exile at Bayonne, but he was allowed to return to Spain later that year following the death of Maria Luisa of Savoy and the subsequent loss of influence of Marie Anne de La Trémoille, princesse des Ursins.

[1] On 12 July 1717 Cardinal Giudice exchanged his titulus of Santa Sabina for the Suburbicarian See of Palestrina, while retaining his post as Archbishop of Monreale.

[1] His funeral was held at San Marcello al Corso on 12 October 1725, with Pope Benedict XIII in attendance.