Francesco was high-ranking among the nobility of the Kingdom of the Two Sicilies, serving as a governmental and military official, and was a knight of three different orders of knighthood.
[3] Upon Carlo's death on 19 July 1823, Francesco inherited his father's titles, including not only Montemiletto but also various other fiefs throughout Italy, and claims.
[5] If any doubts still existed concerning Francesco's rights, his titles were confirmed by Ferdinand II of the Two Sicilies on 11 June 1845, though this was after both of his older brothers had died.
Francesco also served the kingdom in a military capacity, being a colonel of the Reggimento Real Principe cavalleria ('Royal Prince Cavalry Regiment').
[6] On 10 October 1821, Francesco married his cousin Maria Maddalena di Tocco Cantelmo Stuart at Naples.