Later he lived in Mantua and Verona before settling in Milan as the maestro di cappella at the cathedral there, a position which he accepted in January 1484.
During the previous decade the Sforza family, using the composer Gaspar van Weerbeke as a recruiter, had built the choir at their chapel in Milan into one of the largest and most distinguished musical ensembles in Europe: composer-singers such as Alexander Agricola, Loyset Compère and Johannes Martini had all been employed there.
Gaffurius retained the post at the cathedral for the rest of his life, and it was in Milan that he knew both Josquin des Prez and Leonardo da Vinci.
In addition to having a thorough understanding of contemporary musical practice, he met composers from all over Europe, since he had the good fortune to be living and working at one of the centers of activity for the incoming Netherlanders.
Some of the motets were written for ceremonial occasions for his ducal employer; many of the masses show the influence of Josquin, and all are in flowing Netherlandish polyphony, though with an admixture of Italian lightness and melody.