He served as its Founding President while pursuing his undergraduate studies at the Kwame Nkrumah University of Science and Technology (KNUST).

Prior to joining the staff and campaign of Nana Addo Dankwa Akufo-Addo, he held positions at the Ministry of Employment and Social Welfare (MESW), Global Media Alliance (GMA), Delta Acquisitions and Development, Delaware, USA, Michigan House of Representatives, Michigan, USA, Planning Officer at Ghana Free Zones Board (GFZB), a Project Manager for the Tema Export Processing Zone (TEPZ)and a Research Analyst at the Ghana Investment Promotion Center (GIPC).

[8] While working at the Ministry of Employment and Social Welfare (MESW), he was a Development Communication Specialist for a program to eliminate child labour in cocoa growing communities in Ghana.

[12] In January 2017, Francis Asenso-Boakye was appointed the political assistant and Deputy Chief of Staff[13] at the Flagstaff House by President Nana Addo Dankwa Akufo-Addo.

[14][15][16] In June 2020, Asenso-Boakye won the Bantama NPP primaries against the incumbent Daniel Okyem Aboagye in a bid to contest for a seat in the Parliament of Ghana.