Francis Bowes Sayre Sr. (April 30, 1885 – March 29, 1972) was a professor at Harvard Law School, High Commissioner of the Philippines, and a son-in-law of President Woodrow Wilson.

At the start of his career, Sayre worked for Wilfred Grenfell's medical mission in Newfoundland, and as an assistant prosecutor in the office of the New York County District Attorney.On November 25, 1913, Sayre married Jessie Woodrow Wilson (1887–1933), the middle daughter of President Woodrow Wilson, in a ceremony at the White House.

He later served as foreign affairs advisor to the government of King Vajiravudh of Siam as successor to American Foreign Affairs Adviser Edward Henry Strobel, Jens Westengard and Eldon James;[2] Assistant Secretary of State, High Commissioner of the Philippines, and U.S. representative to the United Nations Trusteeship Council.

[5] His daughter Eleanor (1916–2001) was an expert on the Spanish painter Goya and served from 1945 to 1984 as a curator at the Boston Museum of Fine Arts.

Kanlayana Maitri Road, a short street near the Royal Grand Palace in the area of Rattanakosin Island or Bangkok's old town zone.