The Francis Bowes Sayre Sr. Highway or simply the Sayre Highway is a four-to-six lane, 192-kilometre (119 mi), primary national highway that connects Cagayan de Oro, Misamis Oriental[1] to Kabacan, Cotabato.

[2] It traverses the provinces of Misamis Oriental, Bukidnon[3][4][5] and Cotabato.

[6] The highway's name was Route 3 but was changed to Sayre Highway, in honor of Francis Bowes Sayre, Sr., the U.S. Philippine High Commissioner who spearheaded its construction.

[7] It extends southward through central Mindanao for a distance of about 161 kilometers (100 mi), linking the northern and southern arms of Route 1 (Digos–Butuan Highway).

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