[3] Through his acquaintance with Arthur Hildersham and Thomas Hooker, he became disenchanted with the church of England and began to associate himself with Puritan congregations.
Religion in England was still going through a very discordant time, especially when King Charles I ascended the throne in 1625 and married a French Catholic Princess.
Higginson and his Puritan sympathizers were asked to lead the first expedition to New England's Massachusetts Bay Colony and establish preliminary settlements.
The Higginson Fleet brought with them 115 head of cattle, as well as horses and mares, cows and oxen, 41 goats, some conies (rabbits), along with all the provisions needed for setting up households and surviving till they could get crops in.
The Higginson Fleet set sail on the 1 May 1629, arriving in Salem harbor on the 24 June 1629, and was greeted by a small group of settlers, led by John Endecott.
In the following winter, in the general sickness that ravaged the Massachusetts Bay Colony, he was attacked by a fever, which disabled him, and finally caused his death[3] at the age of 43, leaving behind a widow and eight children.