Francis Kirwan (1589–1661) was an Irish Roman Catholic Bishop of Killala.
He returned to Ireland during the 1620s serving as vicar-general from Archbishop Flaithri Ó Maolconaire of Tuam.
He settled in Paris, becoming a close friend of Vincent de Paul.
On his return to Ireland he joined the party of Rinuccini against the Ormonde peace.
When the war in Ireland was over he was left a fugitive and was compelled to return to France in 1655.