Francis Mellus (February 3, 1824 – September 14, 1864) was a Los Angeles County Supervisor and a successful California business man.

In 1839 he came to San Francisco in Mexican Alta California, and was employed as clerk by his brother Henry.

Francis Mellus bought hides for this company along the coast of California, taking the goods by sailing ship to San Diego, where they were dried, and when a sufficient quantity was collected to fill a trading ship, usually took a couple of years' time, Mellus sent the goods to the East Coast.

Francis Mellus was elected to the Los Angeles Common Council, the governing body of the city, on May 1, 1854.

[2] After the ending his partnership with Alexander in 1863, Francis Mellus was representative for the Wells Fargo Express Company until his death in 1864.