He participated as entomologist in a 17-month (1905–1906) expedition to the Galápagos Islands, collecting about 4,000 insects, including many new species.
In 1917, he moved to Honolulu to work for 32 years for the Hawaiian Sugar Planters' Association.
Before he left, he gave his collection of nearly 8000 specimens and his library of 649 books and journals to the California Academy of Sciences.
After his retirement and return to California in 1949, he gave the academy over 15,000 specimens.
He published 286 scientific articles including his most important reference book Handbook of the Insects and Other Invertebrates of Hawaiian Sugar Cane Fields (1931) and a popular book, written with his wife, Louisa Clark Williams, Mike the Mynah (1946).