Numerous grandmasters contributed lavishly towards the embellishment of the church which now hosts various works of art.

The church is the location of the Carnival tragedy of 1823, when many boys were crushed to death in a corridor of the building while waiting to receive bread.

The main attraction is undoubtedly the impressive Miraculous Crucifix (in Maltese: Il-Kurċifiss Mirakuluż),[3] by the Sicilian friar Innocenzo da Petralia Sottana around 1630.

The first victim of the 1813–14 plague epidemic in Malta, a young girl, was buried inside the church, at the lack of knowledge by everyone of the circumstances of her death.

[5] The church hosts the grave of Blessed Nazju Falzon (1813–1865), a diocesan cleric greatly venerated by the Maltese, who taught Catholic catechism to British sailors stationed in Malta.