During his career he represented Sevilla FC, his hometown club, and RCD Espanyol, appearing in 436 La Liga matches.

In the 1992–93 campaign, Francisco experienced top-flight relegation with the Catalans, but achieved promotion the following year always as an important player.

[1] Midway through the 2008–09 campaign, López was sacked as manager of CD Atlético Baleares, also in division three.

[6] Francisco earned 20 caps and scored one goal for Spain, and was selected for both the UEFA Euro 1984 and the 1986 FIFA World Cup tournaments.

One was them was in the 2–0 final loss against the hosts France, due to injury or suspension to three habitual starters.