Francisco Antonio de Lorenzana y Butrón (22 September 1722 – 17 April 1804) was a Catholic Cardinal, who had also earlier served as Archbishop of Mexico.

After the completion of his studies at the Jesuit College of his native city, he entered the ecclesiastical state and was appointed, at an early date, to a canonry in Toledo.

According to one scholar, Lorenzana "became an outspoken critic of the crown's ecclesiastical policy and warned Charles III that his measures were Protestant heresies.

He converted a castle to a workhouse, subsidized the silk industry, and instructed parish priests help peasants on how to improve agriculture.

[2] Lorenzana was among other reformist clerics who put emphasis on improving welfare on earth and not focusing entirely on spiritual life after death.

On the death of Pius VI he made possible the holding of the conclave in Venice (1 December 1799) by providing traveling expenses for some of the cardinals who were penniless.