Francisco Afan Delgado (January 25, 1886 – October 27, 1964) was a Filipino politician and diplomat who served as a Resident Commissioner from the Philippine Islands from 1935 to 1936.

He was elected as a Resident Commissioner to the United States and served from January 3, 1935, until February 14, 1936, when a successor qualified under the new government of the Commonwealth of the Philippine Islands.

He then resumed his law practice and became a delegate to the International Committee of Jurists in Washington, D.C., and to the United Nations Conference in San Francisco, California in April 1945.

Finally, Delgado held the position of Ambassador to the United Nations from September 29, 1958 to January 1, 1962.

Ambassador Delgado was also an active member of the Freemasons, being a Shriner and The Grandmaster of the Grand Lodge of Freemasonry between 1926 and 1927 and founder of the Masonic Hospital for Children in Manila.