In opera, he is seen as a specialist of both baroque[4] and contemporary music and his work in all media is characterised by a highly integrated use of dance and technology as part of the dramaturgy and a keen understanding of the culture being treated.

She recommended Negrin to Gerard Mortier who hired him as a staff assistant director at La Monnaie/De Munt in Brussels for two seasons (1984-1986).

[6] There he continued to learn his trade assisting the directors Patrice Chéreau,[4] Karl-Ernst Herrmann [de], John Cox and Maurice Béjart.

This performance came to the attention of the Southbank Centre which commissioned a production of the reconstruction for the Queen Elizabeth Hall in 1989.

That was the start of an international directing career which, in opera, includes the following productions: In 2024, negrin was the creative director for three special concerts celebrating Andrea Bocelli’s 30 years of career, at the Teatro del Silenzio in Tuscany, featuring stars from music and screen including as Ed Sheeran, Jon Batiste, Will Smith, Brian May, Johnny Depp, Plácido Domingo, Josep Carreras, Shania Twain and more.

In 2020 Francisco Negrin directed the tableau vivant for Louis Vuitton’s Paris fashion week autumn/winter womenswear show.

The following productions have been broadcast on TV: Venus, Les contes d'Hoffman, Una cosa rara (Drottninholm version), Una cosa rara (Valencia version) and Intimissimi on ice 2014 and 2105 were both broadcast in Italy and Spain.