Francisco Palacios (born 25 May 1977) is a Puerto Rican professional boxer who challenged for the WBC cruiserweight title in 2011.

Palacios was born in Bronx, New York but moved to Bayamon, Puerto Rico, at the age of 3.

Before he took up boxing, Palacios played college basketball on a scholarship at North Carolina Central University.

Palacios fought for WBC cruiserweight title, but he lost by split decision after 12-rounded bout.

In his fight in September 2012, he again lost to Włodarczyk, by unanimous decision.