Francisco Ruiz (1476 – 23 October 1528) was a Roman Catholic prelate who served as Bishop of Ávila (1514–1528) and Bishop of Ciudad Rodrigo (1510–1514).

[1][2] He was born in Toledo, Spain and ordained a priest in the Order of Friars Minor.

[2] On 18 November 1509 he was selected by the King of Spain and confirmed by Pope Julius II as Bishop of Ciudad Rodrigo.

[2] On 14 July 1514 he was appointed by the King of Spain and confirmed by Pope Leo X as Bishop of Ávila.

[2] He served as Bishop of Ávila until his death, on 23 October 1528.