Cortés refers to Francisco de las Casas as "mi primo" in his fifth letter to the Spanish Crown.
Cortés rewarded Francisco de las Casas by appointing him a Captain, and giving him the town of Yanhuitlan in encomienda.
In January, 1524, Cortés directed captain Cristóbal de Olid to establish a colony for him in Honduras.
He sailed first to Cuba, to pick up supplies Cortés had arranged for him, where Governor Velázquez convinced him to go and claim the colony he was to found as his own.
Olid sailed from Cuba to the coast of Honduras, coming ashore at Triunfo de la Cruz where he initially settled and declared himself governor.
In another version, Olid escapes and hides in Naco, where las Casas finds him, and kills him in a knife fight.
In 1567, Francisco hired the painter, Andres de Concha, to paint the images on the retablo in the church at Yanhuitlan, Oaxaca, his encomienda.