Francisco de Zúñiga Avellaneda y Velasco (around 1475 - Valladolid, 5 October 1536), member of the House of Zúñiga, III Count of Miranda del Castañar, XII Lord of Avellaneda and other towns, was a Spanish noble and politician.
He was Viceroy of Navarre (1522-1527), member of the Council of State of the Catholic Monarchs and of Charles I of Spain, Mayordomo mayor of the Empress Isabella of Portugal, Grandee of Spain and a Knight of the Order of the Golden Fleece.
When Philip the Handsome died in 1506 and Ferdinand the Catholic became Regent for his "mentally unstable" daughter Joanna of Castile, Francisco de Zúñiga was also sidelined [2].
When Ferdinand the Catholic died in 1516, Francisco de Zúñiga swore allegiance to his grandson and successor Charles I of Spain.
He married María Enríquez de Cárdenas, daughter of Gutierre de Cárdenas Chacón, Grand Commander in León of the Order of Santiago, and his wife Teresa Enríquez, first cousin of King Ferdinand the Catholic.