Born in Nogent-sur-Marne, Val-de-Marne, Signorino made his professional debut with FC Metz, helping it return to Ligue 1 in his second year.

In 2007, following Nantes' relegation from the first division, a host of clubs, including Deportivo de La Coruña, Getafe CF, UD Almería, Birmingham City and Newcastle United expressed an interest in the player.

Eventually, Signorino moved to Getafe on 30 July 2007,[1] making his competitive debut against Tottenham Hotspur in the group stage of the UEFA Cup following a period of injury (2–1 away win, 90 minutes played).

[2] His La Liga debut came on 16 December, featuring 67 minutes as a substitute in a 3–1 home defeat to Villarreal CF.

[4][5][6] In January 2010, after being demoted to third-string left-back, he signed with second division side FC Cartagena on loan; in the last minutes of the following summer transfer window he was cut by Getafe[7] and, subsequently, joined S. du Pays de Charleroi on a one-year contract, appearing regularly for the Belgian team but suffering relegation from the Pro League.