Sir Francis Grenville Clarke KBE (14 March 1879 – 13 February 1955) was an Australian politician.
On 24 July 1901 he married Nina Ellis Cotton, with whom he had six children.
In 1913 he was elected to the Victorian Legislative Council as a non-Labor member for Northern Province.
In 1923 he left the ministry and was elected President of the Victorian Legislative Council, a position he held for the next twenty years.
During this time he changed provinces twice, to Melbourne South in 1925 and Monash in 1937.