Frank Otto Gause (February 11, 1905 – August 15, 1972) was an American football player.

[1] He was a star football player at Minneapolis' North High School in the early 1920s.

[2] He played professional football in the National Football League (NFL) as a center and guard for the Minneapolis Red Jackets.

He appeared in three NFL games, two as a starter, during the 1929 season.

[1] He also played for the Ace Box Lunch team in 1931.