Frank Hereford (July 4, 1825 – December 21, 1891) was a United States representative and Senator from West Virginia.

Born near Warrenton, Fauquier County, Virginia, he completed preparatory studies and graduated from McKendree University (Lebanon, Illinois) in 1845.

He moved to West Virginia and was elected as a Democrat to the Forty-second, Forty-third, and Forty-fourth Congresses and served from March 4, 1871, until January 31, 1877, when he resigned.

Hereford was elected as a Democrat to the U.S. Senate on January 26, 1877, to fill the vacancy caused by the death of Allen Taylor Caperton, but didn't qualify until he resigned from the U.S. House of Representatives.

He resumed the practice of law and died in Union, West Virginia in 1891.