Isaac Edward Holmes (April 6, 1796 – February 24, 1867) was a U.S. Representative from South Carolina.

[1] He attended the common schools, received private tuition, and graduated from Yale College in 1815.

He served as member of the Charleston city council and then in the South Carolina House of Representatives in 1826-1829 and 1832-1833.

After his tenure in Congress, he practiced law in San Francisco, California, from 1851 to 1854, when he returned to Charleston, South Carolina.

He returned to South Carolina in 1861 and was appointed a commissioner of the state to confer with the federal government prior to the outbreak of the Civil War.