His career in the European Commission began in 2001 initially working in DG Enlargement and then in legal services.
Hoffmeister was a United Nations Special Advisor on Cyprus and an OSCE election observer in Macedonia.
As of November 2021 Hoffmeister is Director for General Affairs and Chief Legal Officer of the European External Action Service.
[6] Hoffmeister joined the pro-European German civil society association Europa-Union in 2004 and became a board member of the Brussels branch thereof.
The Association organizes pluralistic debates about European topics, and Hoffmeister frequently acts as moderator or panelist in such events.