Little's official debut was as Normanno in Lucia di Lammermoor, in 1970, at the Lyric Opera of Chicago, his first of many appearances with that theatre, including the world premiere of Penderecki's Paradise Lost (as Michael), in 1978, which was seen at the Teatro alla Scala the following year.
He then portrayed Jonas in John Dexter's new production of Le prophète, with Marilyn Horne, Renata Scotto (later Rita Shane), and James McCracken, also in 1977.
From 1978 to 1980, Little sang Cassio in Otello, opposite Jon Vickers (later Richard Cassilly), Katia Ricciarelli, and Cornell MacNeil, conducted by James Levine.
In 1980 and 1981, Little was heard as The Painter/The African Prince in the Met's premiere of the completed version of Lulu, with Teresa Stratas (later Julia Migenes), conducted by Levine, in Dexter's production, which was televised.
Elsewhere, the tenor was heard with the companies in Vancouver, Florence, Canary Islands, Milwaukee, New Orleans (Ægisth in Elektra, 1982), Philadelphia, San Antonio, Washington DC, etc.