In 1975, while looking for work in publishing or illustrating, Margerin met Jean-Pierre Dionnet, who ordered his first comic strip, a four-page parodical science fiction story named "Simone et Léon", for the Métal Hurlant magazine.

With Ricky's and later Lucien's stories, Margerin comically described the life of suburban French rockers of the late 1970s and early 1980s.

In 1989, Les Humanoïdes Associés gave him the direction of a series of collective albums with the common title Frank Margerin présente...

He also created Y'a plus de jeunesse for Albin Michel and worked on an animated television series, Manu, which was first broadcast on Antenne 2 in 1990.

In 1992, Margerin received the Grand Prix de la ville d'Angoulême at the Angoulême International Comics Festival.